Endocrine Abstracts

Aim: It is well known that there is a strong relationship between chronic inflammation and tumorigenic process. The cytological diagnosis of follicular neoplasm (FN) carries a 20–30% risk of malignancy for thyroid nodules. In this study, we aimed to evaluate whether preoperative neutrophil to lymphocyte ratio (NLR) is a predictive factor for malignancy in thyroid nodules diagnosed as FN on cytology.Materials and methods: A total of 139 patients with...

Addison’s disease (AD), is an autoimmune disorder. However, its association with connective tissue diseases is rare. Here, we report a case of AD associated with ankylosing spondylitis (AS).Case: A 57-year-old male patient admitted to internal medicine polyclinic with complaints of debility and anorexia. In the physical examination, he has hyperpigmentation on his skin, gingiva and palm lines. Blood pressure was 80/50 mmHg, pulse was 64/min. The oth...

Introduction: Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced responsiveness of target tissues to thyroid hormone (TH). It is characterized by high serum concentrations of free T4 (Ft4) and usually free T3 (Ft3) accompanied by normal or slightly high serum TSH concentrations. When RTH is suspected, the diagnosis should be confirmed by direct sequencing of the TR-β gene to identify mutations....

Aim: Basal energy expenditure (BEE), also called basal metabolic rate, increases in cancer patients and is thought to contribute to the weight loss observed in cancer cachexia. Cancer type, pathological stage and duration of disease influence BEE. The aim of this study was to evaluate BEE and body composition in breast cancer patients.Methods: Forty-three women with breast cancer whose received adjuvant chemotherapy and 80 healthy age and body mass index...

Introduction: Riedel’s thyroiditis (RT) is a rare and chronic fibro-inflammatory disease firstly described by Riedel in 1896. It is characterized by a dense fibrosis that replaces normal thyroid parenchyma. The fibrotic process invades adjacent structures of the neck and extends beyond the thyroid capsule, which differentiates RT from other inflammatory or fibrotic disorders of the thyroid. The overall incidence in outpatients is 1.06 per 100 000. We presented here a case...

Objective: Platelet activation and aggregation play major role in the pathophysiology of atherothrombosis. Mean platelet volume (MPV), a determinant of platelet function, is a newly emerging risk factor for atherosclerosis. The present study was designed to evaluate levels of MPV before and after the levothyroxine (L-T4) treatment in patients with overt hypothyroidism.Materials and methods: The study included 30 Hashimoto’s...

Purpose: Numerous epidemiological studies have shown that obesity is a risk factor for postmenopausal breast cancer and relapse. We aim to investigate the relation between the upper abdominal obesity and breast cancer, by using ultrasonography (USG).Material and methods: The study population consisted of 44 women in control group and 17 breast cancer patient in study group. In the whole study population fat tissue was measured with high resolution B-mode...

Aim: Diabetic foot is a devastating complication of diabetes mellitus. Many factors such as neuropathy, vascular injury and infection contribute in the development of diabetic foot. Programmed cell death is a pathway that causes a tendency for the development of atherosclerosis. Whereas Fas/Fas ligand pathway induces apoptosis, osteoprotegerin (OPG) causes calcification in vascular area and also effects apoptotic pathway. In the present study, we aimed to investigate the role ...

Primary hyperparathyroidism in the most common cause of hypercalcemia. 87% of the cases present with single adenoma, 9% of them have hyperplasia, while multiple adenomas and parathyroid malignancy are detected in 3 and 1% of the cases, respectively. Although it is rare, parathyroid adenomas may be ectopic. The most common locations for ectopic parathyroid adenomas are thymus, tracheaesophageal cleft, carotis sheet, intrathyroidal and paraesophageal area. In this study, we aime...

Acromegaly affects 4–6 people in a million and hypophyseal GH releasing adenoma is the most common cause of the disease. It shows its effects on GH and IGF1. Since they grow rapidly, they are usually diagnosed at the stage of macroadenomas. Heart failure, arthritis, OSAS and DM may develop during course of the disease. Although the most common accompanying malignancy is colon cancer, the incidence of malign melanoma, breast, thyroid, gastric and lung cancers is also incre...